US 52 is a favorite road-trip for street bikes.
In addition, some of the best ATV / Off-Road Motorcycle riding in the country is located in McDowell County, West Virginia.
Relaxed laws in McDowell County allow ATV's to be driven on all public roads which allows easy access to ATV trails such as the Hatfield McCoy trails
http://www.trailsheaven.com/ which is located in nearby Northfork.